Glutamate toxicity and meningitis

22 October 2015 at 18:12:48 by Sarissa Bio

Sarissa's glutamate biosensors used to measure glutamate release in brain in a model of meningitis. The authors show that pneumolysin causes glutamate release from astrocytes and induce excytotoxic damage. See the paper:

Wippel C, Maurer J, Fortsch C, Hupp S, Bohl A, Ma J, Mitchell TJ, Bunkowski S, Bruck W, Nau R, Iliev AI (2013) Bacterial Cytolysin during Meningitis Disrupts the Regulation of Glutamate in the Brain, Leading to Synaptic Damage. PLoS pathogens 9:e1003380.

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