ATP and the BOLD response

15 May 2015 at 00:00:00 by Sarissa Bio

The fMRI BOLD signal forms the basis of almost all modern functional brian imaging studies. The origins of this signal remain unclear. A superb new paper establishes a link between the rapid activity-depdendent release of ATP and the generation of fMRI BOLD responses in somatosensory cortex. This is a landmark paper that changes the field, and Sarissa's ATP biosensors helped the authors to develop the evidence to substantiate their findings.

Wells J et al (2015) A critical role for purinergic signaling mechanisms underlying BOLD fMRI repsonses. J Neurosci 35: 5284-5292

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