Glutamate biosensors and stroke treatments
27 November 2014 at 00:00:00
by Sarissa Bio
Trotman M, Vermehran P, Gibson CL, Fern R (2014) The dichotomy of memantine treatment for ischemicstroke: dose-dependent protective and detrimental effects. J Cereb Blood Flow & Metab doi:10.1038/jcbfm.2014.188
This new paper examing the mechanisms of excitotoxic cell death relevant to stroke. The paper comes to the surprising conclusion that low doses of memantine give over a prolonged period was neuroprotective, but high doses exacerbated cell pathology.
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