Glutamate biosensors and stroke treatments

27 November 2014 at 00:00:00 by Sarissa Bio

Trotman M, Vermehran P, Gibson CL, Fern R (2014) The dichotomy of memantine treatment for ischemicstroke: dose-dependent protective and detrimental effects. J Cereb Blood Flow & Metab doi:10.1038/jcbfm.2014.188

This new paper examing the mechanisms of excitotoxic cell death relevant to stroke. The paper comes to the surprising conclusion that low doses of memantine give over a prolonged period was neuroprotective, but high doses exacerbated cell pathology.

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