Glutamate biosensors and stroke treatments

Trotman M, Vermehran P, Gibson CL, Fern R (2014) The dichotomy of memantine treatment for ischemicstroke: dose-dependent protective and detrimental effects. J Cereb Blood Flow & Metab doi:10.1038/jcbfm.2014.188

This new paper examing the mechanisms of excitotoxic cell death relevant to stroke. The paper comes to the surprising conclusion that low doses of memantine give over a prolonged period was neuroprotective, but high doses exacerbated cell pathology.