Exocytosis of adenosine

20 March 2012 at 00:00:00 by sarissa2

In this paper sarissaprobe Ado biosensors were used to demonstrate direct action potential dependent release of adenosine from parallel fibres in the cerebellum. The authours used a mouse line lacking a key extracellular enzyme that converts ATP to adenosine to demosntrate that this was direct release of adenosine rather than adenosine arising from previously released ATP. Furthermore this direct release of adenosine was blocked by bafilomycin leading the authors to the revolutionary conclusion that adenosine can be released by exocytosis.

Klyuch, B., Dale, N. and Wall, M. (2012) Deletion of ecto-5'-nucleotidase (CD73) reveals direct action potential-dependent adenosine release. J Neurosci 32:3842-3847.

 

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