Adenosine and homeostatic control of synaptic activity

15 November 2012 at 00:00:00 by sarissa2

A new paper using Sarissa's adenosine biosensors shows the importance of adenosine kinase in regulating the release of adenosine in brain. This important evidence supports the idea that adenosine kinase is a a key therapeutic target for treating neurological conditions such as epilepsy.

Diogenes MJ, Raquel NT, Fucile S, Martinello, K, Scianni M, Theofilas, P Lopatar J,  Ribiero JA, Maggi L, Frenguelli BG, Limatola C, Boison D, Sebastiao AM (2012) Homeostatic Control of Synaptic Activity by Endogenous Adenosine is Mediated by Adenosine Kinase. Cerebral Cortex doi:10.1093/cercor/bhs284.

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