Sarissa's glutamate biosensors used to measure glutamate release in brain in a model of meningitis. The authors show that pneumolysin causes glutamate release from astrocytes and induce excytotoxic damage. See the paper:
Wippel C, Maurer J, Fortsch C, Hupp S, Bohl A, Ma J, Mitchell TJ, Bunkowski S, Bruck W, Nau R, Iliev AI (2013) Bacterial Cytolysin during Meningitis Disrupts the Regulation of Glutamate in the Brain, Leading to Syn ... Read More
In a departure from applications of our biosensors to Neuroscience, researchers in the Medical College of Wisconsin have used ATP and Null sarissaprobes to record ATP release and peroxide production in the kidney. This is the first published work using Sarissa's biosensors in the kidney.
In their recent paper "Real-tim ... Read More
To share with you all the beauty of biosensor recordings we have created a set of Examples pages that illustrate recordings of various sarissaprobes in action. These will be continually updated, so watch this space!
Mon ... Read More
A new paper using Sarissa's adenosine biosensors shows the importance of adenosine kinase in regulating the release of adenosine in brain. This important evidence supports the idea that adenosine kinase is a a key therapeutic target for treating neurological conditions such as epilepsy.