On this set of pages we show some examples of sarissaprobes in
action. These examples are illustrative of the ability of our
biosensors to measure transmitter and metabolite release in real
time in conjunction with other physiological measurements both
in vitro and in vivo.
The ability to measure neurotransmitter release directly opens up
new opportunities to understand their actions, functional
significance and release mechanisms, and allows manipulations such
as use of TTX, removal of extracellular calcium or sodium
ions, which are not possible with indirect methods for inferring
transmitter concentration as these often rely on monitoring
synaptic transmission electrophysiologically.
We encourage all potential users to consult the papers listed in
the Publications pages to get a
fuller picture of what our biosensors can be used for and the types
of information they provide.